Oxidative Phosphorylation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
All top hub genes are subunits of the mitochondrial electron transport chain: NDUFB2 (Complex I), UQCR10/UQCRQ/UQCR11 (Complex III/ubiquinol-cytochrome c reductase), COX7B/COX6A1/COX7A2 (Complex IV/cytochrome c oxidase), ATP5MF/ATP5MG/ATP5PF (Complex V/ATP synthase). UBL5 is a ubiquitin-like protein involved in mitochondrial function. All genes are core members with uniform expression. Strongly downregulated in inflammation and restored by treatment, consistent with mitochondrial dysfunction in IBD. Neighbor M39 shares the same OxPhos identity with overlapping COX and UQCR subunits.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.98
- Mitochondrial Membrane · correlation 0.96
- ER Protein Processing · correlation 0.94
- Mitochondrial Complex I · correlation 0.93
- Mitochondrial Sulfur Detox · correlation 0.93
- TCA Cycle OxPhos · correlation 0.93
- Oxidative Phosphorylation · correlation 0.92
- Co-translational Chaperoning · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.