Epithelial Metabolic Homeostasis
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub gene ITGAE (integrin alpha-E/CD103) mediates epithelial retention and cell-matrix adhesion. EXOSC3 is part of the RNA exosome complex (RNA surveillance/processing). SHMT2 encodes mitochondrial serine hydroxymethyltransferase, a key enzyme in one-carbon/folate metabolism supporting nucleotide synthesis. TMEM70 is required for mitochondrial ATP synthase assembly. EIF2S1 (eIF2alpha) is a translation initiation factor also central to the integrated stress response. SNRPA1 is a snRNP component (splicing). AIMP2 is part of the multi-aminoacyl-tRNA synthetase complex. RUVBL2 is an AAA-ATPase involved in chromatin remodeling. The module is significantly decreased in CD inflammation and restored by treatment. The combination of ITGAE with metabolic/RNA processing genes suggests a mixed module in epithelial progenitors with adhesion and metabolic maintenance programs co-regulated in homeostasis.
Genes
Most correlated modules
- Mitochondrial Metabolism · correlation 0.89
- ER Stress UPR · correlation 0.86
- DNA Damage Repair · correlation 0.86
- Housekeeping Transcription · correlation 0.85
- Chromatin RNA Processing · correlation 0.83
- Nuclear RNA Transport · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.