Nuclear RNA Transport
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub gene GGCT (gamma-glutamylcyclotransferase) is involved in glutathione metabolism and stress response. RANBP1 (RanGTPase-binding protein 1) regulates nuclear-cytoplasmic transport. SIVA1 is a pro-apoptotic protein regulated by p53 and CD27. RPA3 (replication protein A 32kDa subunit) is essential for DNA replication and repair. DCTPP1 (dCTP pyrophosphatase) maintains nucleotide pool balance. EIF4EBP1 (4E-BP1) is a key mTOR pathway effector regulating cap-dependent translation. MRPL17 (mitoribosomal), ALYREF (mRNA export/transcription-export complex), SNRNP25 (U11/U12 snRNP, minor spliceosome), POLR3K (RNA Pol III subunit), AKR7A2 (aldo-keto reductase, detoxification), HPRT1 (hypoxanthine-guanine phosphoribosyltransferase, purine salvage), CKLF (chemokine-like factor). The module is mixed but the strongest coherent program involves RNA processing/nuclear transport (RANBP1, ALYREF, SNRNP25, POLR3K) combined with nucleotide metabolism (HPRT1, DCTPP1, RPA3). EIF4EBP1 links to mTOR/translation control. Given the neighbor context (M44 splicing, M74 snRNP), the RNA processing/nuclear transport theme is most consistent. The module is genuinely mixed — housekeeping with stress/apoptosis elements.
Genes
Most correlated modules
- Mitochondrial Metabolism · correlation 0.93
- snRNP RNA Processing · correlation 0.93
- snRNP Splicing Complex · correlation 0.92
- TRiC Chaperonin Complex · correlation 0.91
- Chromatin RNA Processing · correlation 0.87
- Nuclear Housekeeping · correlation 0.84
- Epithelial Metabolic Homeostasis · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.