DNA Damage Repair
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub PRKDC encodes DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase central to non-homologous end joining (NHEJ) DNA repair. BRI3BP is associated with apoptosis/DNA damage response. PSMD1 is a proteasome 26S regulatory subunit (proteostasis). NAA50 is an N-terminal acetyltransferase involved in DNA damage tolerance. GMPS (GMP synthase) supports nucleotide biosynthesis for repair. IPO5 (importin-5) and KPNB1 neighbor context suggest nuclear import of repair factors. DIAPH1 (formin) and CKAP4 are cytoskeletal/ER. NFIC is a transcription factor. The module is decreased in CD inflammation and restored by treatment, suggesting a DNA repair/genome maintenance program suppressed during active inflammation.
Genes
Most correlated modules
- Housekeeping Transcription · correlation 0.90
- Chromatin RNA Processing · correlation 0.88
- Epithelial Cell Adhesion · correlation 0.87
- Epithelial Metabolic Homeostasis · correlation 0.86
- Protein Glycosylation · correlation 0.83
- Metabolic Housekeeping · correlation 0.82
- Mitochondrial Cristae Organization · correlation 0.81
- ER Stress UPR · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.