ER Stress UPR
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Top hub genes SDF2L1, CRELD2, and MANF are canonical ER stress/unfolded protein response (UPR) markers strongly induced during ER stress. LRRC59 and SURF4 are ER membrane proteins involved in ER-Golgi trafficking. ADRM1 and PSMC3 are proteasome components involved in ERAD (ER-associated degradation). ARPC1B and TAGLN2 are actin-related but may reflect stress-induced cytoskeletal remodeling. The module is significantly upregulated in both UC and CD inflammation, consistent with ER stress being a hallmark of inflamed intestinal epithelium. Neighbor context with M86 (DNA repair/proteasome) supports a shared proteostasis stress theme.
Genes
Most correlated modules
- ER Stress UPR · correlation 0.91
- Metabolic Housekeeping · correlation 0.89
- Mitochondrial Metabolism · correlation 0.88
- Epithelial Metabolic Homeostasis · correlation 0.86
- Metabolic Housekeeping · correlation 0.86
- Inflammatory Lipid Stress · correlation 0.81
- Chromatin RNA Processing · correlation 0.81
- DNA Damage Repair · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.