Chromatin RNA Processing
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include KPNB1 (importin-beta nuclear transport), HNRNPA3/HNRNPR/HNRNPD (hnRNP RNA-binding proteins), CBX3 (HP1-gamma heterochromatin), DEK (chromatin/RNA processing), SSRP1 (FACT chromatin remodeling complex), HMGN1 (nucleosome binding), and PTMA (chromatin decondensation). The module is dominated by chromatin-associated and nuclear RNA-processing factors. Uniform expression across subsets, moderate disease signal. The combination of hnRNPs with chromatin regulators reflects coupled transcription-splicing programs typical of actively transcribing progenitor cells.
Genes
Most correlated modules
- TRiC Chaperonin Complex · correlation 0.94
- Housekeeping Transcription · correlation 0.92
- Mitochondrial Metabolism · correlation 0.90
- RNA Processing Translation · correlation 0.88
- DNA Damage Repair · correlation 0.88
- Nuclear Architecture · correlation 0.88
- Nuclear RNA Transport · correlation 0.87
- Nuclear Housekeeping · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.