Mitochondrial Metabolism
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
This module contains MRPS16, MRPL37, and MRPL27 (mitoribosomal subunits), IDH2 (isocitrate dehydrogenase 2, TCA cycle/mitochondrial), OXCT1 (succinyl-CoA:3-oxoacid CoA transferase, ketone body oxidation in mitochondria), CLPP (mitochondrial caseinolytic protease), and ACAT2 (acetyl-CoA acetyltransferase, ketone/cholesterol metabolism). EBP (emopamil-binding protein, cholesterol biosynthesis), ZDHHC12 (palmitoyl transferase, lipid modification), PLP2 (proteolipid protein 2), NUCB2 (nucleobindin-2, calcium/ER). CCT5 (TRiC chaperonin subunit — neighbor to M22's CCT2/6A/8), LSM4 (splicing), TMEM106C (lysosomal), AP2S1 (clathrin-mediated endocytosis), GGH (gamma-glutamyl hydrolase, folate metabolism), XRCC6 (Ku70, DNA repair). The mitochondrial metabolic genes (IDH2, OXCT1, CLPP, MRPS16, MRPL37, MRPL27, ACAT2) form the strongest coherent program. Neighbor context: M6 (Complex I) and M44 (mitoribosomal) are neighbors, supporting a mitochondrial metabolic theme.
Genes
Most correlated modules
- snRNP RNA Processing · correlation 0.94
- Nuclear RNA Transport · correlation 0.93
- ER Protein Trafficking · correlation 0.92
- Metabolic Housekeeping · correlation 0.92
- TRiC Chaperonin Complex · correlation 0.92
- snRNP Splicing Complex · correlation 0.91
- Chromatin RNA Processing · correlation 0.90
- Epithelial Metabolic Homeostasis · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.