DPP4+ Progenitor State
Gene co-expression module in Lymphatic endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
DPP4 is the top hub gene and marks a stromal/progenitor endothelial subset. ADAMTS6 and SBSPON are ECM-remodeling/matrix proteins. CD24 is a cell adhesion/surface marker. GSTM3 reflects detoxification capacity. ISYNA1 (inositol synthesis) and PIK3C2G (PI3K signaling) suggest metabolic/signaling activity. TCTN3 is cilia-associated. The module has low expression and pct positive, suggesting a rare cell state. In the context of neighbor M64 (ECM/quiescence), this module may represent a DPP4+ progenitor-like lymphatic subset with active ECM remodeling.
Genes
ADAMTS6, CD24, DPP4, GSTM3, ISYNA1, PIK3C2G, SBSPON, TCTN3
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.