TCTN3 — Tectonic family member 3
TCTN3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TCTN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Activated B cell B cell maturation | ARHGAP25, ARID3A, CFLAR, DUSP4, ENTPD1, MYO1F, PIK3R5, PLXNC1 +6 more | View in SCUBA |
| Innate lymphoid cells | Prostaglandin-AP1 Response Inflammation | ARIH1, ARL5B, CCNT1, CHD1, CXCL2, ETV3, FOSL2, IRF2BP2 +12 more | View in SCUBA |
| Lymphatic endothelial | DPP4+ Progenitor State migration & adhesion | ADAMTS6, CD24, DPP4, GSTM3, ISYNA1, PIK3C2G, SBSPON | View in SCUBA |
About the gene
| Synonyms | C10orf61, DKFZP564D116, JBTS18, TECT3 |
|---|---|
| Chromosome | 10: 95659823-95694143 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Apoptosis, Cilium biogenesis/degradation |
Function
Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.