GSTM3 — Glutathione S-transferase mu 3
GSTM3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GSTM3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Hypoxia metabolic stress Stress | ARG2, ARL4D, AXIN2, BNIP3, CITED4, CNKSR2, GCA, ID3 +13 more | View in SCUBA |
| Gamma-delta T cells | cAMP Lipid Signaling Immune regulation | ABL1, AKIRIN2, B9D2, CEMIP2, CHPT1, CTDP1, DKK3, GGA2 +15 more | |
| Lymphatic endothelial | DPP4+ Progenitor State migration & adhesion | ADAMTS6, CD24, DPP4, ISYNA1, PIK3C2G, SBSPON, TCTN3 | View in SCUBA |
| Smooth muscle cells | Basal metabolic housekeeping Housekeeping | AP2S1, CNN2, GNG5, IMPDH2, KIF5B, OSTC, PRDX4, VDAC3 | View in SCUBA |
About the gene
| Synonyms | GST5 |
|---|---|
| Chromosome | 1: 109733932-109741038 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.