ISYNA1 — Inositol-3-phosphate synthase 1
ISYNA1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ISYNA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Gut-homing Residence Tissue residence | ADAM28, ASB2, ATP8B4, CAPG, CCR9, CD101, CD9, DAPK2 +8 more | |
| Lymphatic endothelial | DPP4+ Progenitor State migration & adhesion | ADAMTS6, CD24, DPP4, GSTM3, PIK3C2G, SBSPON, TCTN3 | View in SCUBA |
| Natural Killer cells | NK Checkpoint Receptors Immune regulation | CD7, CD96, CRACR2B, DAPK2, ECH1, ECI2, KIR2DL4, MAP4 +5 more | View in SCUBA |
| Smooth muscle cells | Pericyte Signature Development | AC100803.3, CCND1, COX4I2, CPM, ENTPD3, GPR20, GPRIN3, GRIP2 +8 more | View in SCUBA |
About the gene
| Synonyms | Ino1, INOS, IPS |
|---|---|
| Chromosome | 19: 18434388-18438167 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Isomerase |
| Biological process | Inositol biosynthesis, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Function
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.