OxPhos & Mitochondrial
Gene co-expression module in Microfold-like cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include EEF1D (translation elongation factor), ATP5F1D (ATP synthase subunit, Complex V), COX20 (Complex IV assembly factor), CHCHD10 (mitochondrial intermembrane space protein, OxPhos assembly), ATP5ME (ATP synthase subunit e), TFF3 (trefoil factor 3, secretory/goblet cell marker), PPP1R1B (DARPP-32, phosphatase inhibitor), PHGR1 (proline/histidine/glycine-rich, intestinal secretory), PNKD (paroxysmal dyskinesia gene, mitochondrial), SAP18 (Sin3A-associated, chromatin). The module combines mitochondrial OxPhos assembly (ATP5F1D, COX20, CHCHD10, ATP5ME) with secretory cell markers (TFF3, PHGR1), suggesting co-expression of mitochondrial and secretory programs in M-like/goblet-adjacent cells. The OxPhos component dominates by gene count and PageRank. TFF3 and PHGR1 may reflect a secretory cell subpopulation overlap.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.98
- OxPhos & Mitochondrial · correlation 0.98
- OxPhos & Mitochondrial · correlation 0.97
- Intestinal Stem Cell · correlation 0.96
- mRNA Splicing Processing · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.