Heat Shock Response
Gene co-expression module in Microfold-like cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
HSPH1 (HSP110, large heat shock protein), DNAJB6 (DnaJ/Hsp40 co-chaperone), CCDC47 (ER membrane chaperone), LRRC59 (ER membrane protein), and BPTF (NURF chromatin remodeling) are the dominant functional genes. HSPH1 and DNAJB6 are canonical heat shock/chaperone proteins. CCDC47 and LRRC59 are ER-associated. CSNK1A1 (casein kinase 1α) phosphorylates beta-catenin for degradation (WNT pathway). ZFP36L1 mediates mRNA decay under stress. IQGAP1 is a cytoskeletal scaffold. The module is most coherently a heat shock/chaperone response program, with ER membrane components, placing it as a neighbor to M38 and M2 in the proteostasis neighborhood. Significantly restored by CD treatment.
Genes
Most correlated modules
- Oxidative Stress Response · correlation 0.99
- WNT Beta-catenin · correlation 0.99
- ER Protein Folding · correlation 0.98
- Apoptosis Regulation · correlation 0.98
- Chaperone Proteostasis · correlation 0.98
- Macrophage Homeostasis · correlation 0.97
- mRNA Splicing Processing · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.