BMP-ECM Signaling
Gene co-expression module in Microfold-like cells
| Category | Intercellular communication |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
BMP2 (bone morphogenetic protein, TGF-β superfamily morphogen with roles in intestinal homeostasis and macrophage polarization), FN1 (fibronectin, major ECM glycoprotein), TES (tessin, focal adhesion/ECM interaction), and TRIB1 (tribbles-1, macrophage differentiation and lipid metabolism regulator) are the dominant functional anchors. AKIRIN1 (NF-κB/innate immunity nuclear effector), BTG3 (anti-proliferative), CERS6 (ceramide synthase, lipid signaling), SINHCAF (Sin3 chromatin repressor), and CELF2 (RNA binding) are supporting members. VPS35 (retromer) and LEPROT are peripheral. The BMP2-FN1-TES axis suggests ECM-morphogenic signaling in macrophage-like cells, consistent with tissue remodeling context. Significant decrease with CD inflammation supports a homeostatic/anti-inflammatory role.
Genes
Most correlated modules
- Intracellular Cargo Transport · correlation 0.99
- Membrane Remodeling mTOR · correlation 0.98
- ER Redox Homeostasis · correlation 0.98
- Endosomal Vesicle Trafficking · correlation 0.98
- Growth Arrest Stress · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.