ER Redox Homeostasis
Gene co-expression module in Microfold-like cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
SELENOK and SELENOT (ER-resident selenoproteins critical for ER redox homeostasis), ERP44 (ER oxidoreductase/thiol-disulfide exchange), DERL1 (derlin-1, ERAD retrotranslocation channel), TMBIM4 (BI-1, ER Ca2+ regulator and anti-apoptotic), PON2 (ER-associated antioxidant paraoxonase), and GALNT1 (Golgi O-glycosyltransferase) define a strong ER redox and homeostasis program. ANXA7 (membrane fusion/Ca2+), CHMP5 (ESCRT-III), GABARAPL2 (autophagy/mitophagy), TM9SF2 (lysosomal), and ACTR3 (Arp2/3) are supporting members reflecting ER-to-lysosome quality control. PGK1 and MRPL22 are peripheral. Neighbors M92 and M50 share vesicular/ER trafficking themes, supporting this ER-centric label.
Genes
Most correlated modules
- Membrane Remodeling mTOR · correlation 0.99
- Endosomal Vesicle Trafficking · correlation 0.99
- Lysosomal Lipid Catabolism · correlation 0.99
- Intracellular Cargo Transport · correlation 0.99
- Actin & Membrane · correlation 0.98
- Macrophage Homeostasis · correlation 0.98
- Inflammatory Myeloid · correlation 0.98
- BMP-ECM Signaling · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.