Endosomal Vesicle Trafficking
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes RAB7A (late endosomal trafficking), AP1M2 (adaptor protein complex for vesicle sorting), RAP1B (vesicle-associated GTPase), ARPC2 (Arp2/3 actin branching for endocytosis), VASP (actin dynamics), and SDCBP (endosomal scaffold) collectively define an endosomal vesicle trafficking program. HSPA5/BiP and FKBP1A add ER protein folding context, while CASK and RTCB are scaffolding/RNA repair components. The dominant signal is intracellular vesicular transport and endosomal sorting, consistent with macrophage-like cell phagocytic/endosomal activity.
Genes
Most correlated modules
- Intracellular Cargo Transport · correlation 0.99
- Growth Arrest Stress · correlation 0.99
- Macrophage Homeostasis · correlation 0.99
- ER Redox Homeostasis · correlation 0.99
- Membrane Remodeling mTOR · correlation 0.99
- Actin & Membrane · correlation 0.99
- Macrophage Phagocytic · correlation 0.99
- Epithelial Identity · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.