Growth Arrest Stress
Gene co-expression module in Microfold-like cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
GADD45A (DNA damage/growth arrest response), PDCD4 (translation inhibitor, tumor suppressor, stress-induced), G3BP2 (stress granule nucleator), and TAX1BP1 (NF-κB negative regulator, autophagy receptor) collectively point to a cellular stress and growth arrest program. SKAP2 (immune signaling adaptor), MORF4L1 (NuA4 chromatin complex), and ADD3 (cytoskeletal adducin) are supporting members. PKP2 (desmosomal plakophilin) and PTPRF (receptor phosphatase) are peripheral. The significant decrease with CD treatment suggests this stress/growth-arrest program is modulated by therapy. SI (sucrase-isomaltase) is likely a peripheral or contaminating gene.
Genes
Most correlated modules
- Macrophage Homeostasis · correlation 0.99
- Endosomal Vesicle Trafficking · correlation 0.99
- Actin Cytoskeletal Regulation · correlation 0.98
- Autophagy Lysosomal · correlation 0.98
- Intracellular Cargo Transport · correlation 0.98
- Colonocyte Epithelial · correlation 0.98
- Macrophage Homeostasis · correlation 0.98
- Macrophage Phagocytic · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.