Intestinal Stem Cell
Gene co-expression module in Microfold-like cells
| Category | Stemness |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include EPHB2 (Wnt/stem cell niche receptor marking crypt progenitors), RSL1D1 and NHP2 (ribosome biogenesis/nucleolar), FBL (rRNA methylation), SET (chromatin/nucleosome assembly), HSPE1 (mitochondrial chaperonin), SOD2 (mitochondrial antioxidant), RHOV (Rho GTPase), and HMGN3 (chromatin). EPHB2 is a canonical intestinal stem/progenitor marker. The module is downregulated in inflammation and restored with treatment, consistent with a stem/progenitor program suppressed during active IBD. The nucleolar and ribosome biogenesis genes (RSL1D1, NHP2, FBL) support active proliferative/stem cell metabolism. Neighbor modules are largely housekeeping/metabolic, but EPHB2 anchors this as a stem-cell-enriched program.
Genes
Most correlated modules
- OxPhos & Mitochondrial · correlation 0.98
- RNA Processing Homeostasis · correlation 0.98
- Colonocyte Differentiation · correlation 0.98
- ER Protein Homeostasis · correlation 0.98
- Antigen Presentation Housekeeping · correlation 0.98
- Inflammatory Activation Stress · correlation 0.97
- Metabolic Housekeeping · correlation 0.96
- Chromatin Stress Recovery · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.