Colonocyte Metabolic Homeostasis
Gene co-expression module in Microfold-like cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include PFKL (phosphofructokinase-L, glycolysis), HADH (hydroxyacyl-CoA dehydrogenase, fatty acid oxidation), MRPL12 (mitochondrial ribosomal protein), TIMM13 (mitochondrial import translocase), SELENBP1 (selenium binding protein 1, colonocyte differentiation marker), DHRS11 (short-chain dehydrogenase), MT2A (metallothionein 2A, metal stress/detox), HLA-DRA (MHC class II, antigen presentation), SFN (14-3-3σ, stress/epithelial), CENPX (centromere protein). The module combines colonocyte metabolic identity (SELENBP1, PFKL, HADH) with mitochondrial function (MRPL12, TIMM13) and some antigen presentation (HLA-DRA). The metabolic/mitochondrial theme is dominant. As a neighbor to M58 and M62, this likely represents a complementary colonocyte metabolic homeostasis program.
Genes
Most correlated modules
- Inflammatory Activation Stress · correlation 0.96
- Colonocyte Differentiation · correlation 0.96
- Intestinal Stem Cell · correlation 0.96
- Absorptive Colonocyte Identity · correlation 0.96
- Colonocyte Lipid Ion Transport · correlation 0.96
- Interferon Antigen Processing · correlation 0.95
- Colonocyte Proliferative Recovery · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.