Antigen Presentation Housekeeping
Gene co-expression module in Microfold-like cells
| Category | Antigen handling |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes SUCLG2 (succinate-CoA ligase, TCA cycle/mitochondrial), HLA-DPA1 (MHC class II antigen presentation), GSPT1 (translation termination), PA2G4 (ribosome biogenesis/translation), ARF6 (vesicle trafficking/membrane), PPP1CC (protein phosphatase 1), YWHAQ (14-3-3 theta, signaling scaffold), IL32 (pro-inflammatory cytokine), CDK2AP2 (CDK2 inhibitor), PTBP1 (RNA splicing), PRKDC (DNA-PK, DNA repair). Module is significantly upregulated by CD treatment. The gene set is mixed: mitochondrial metabolism (SUCLG2), antigen presentation (HLA-DPA1), translation (GSPT1, PA2G4), signaling (YWHAQ, PPP1CC, ARF6), and inflammation (IL32). The presence of HLA-DPA1 and IL32 alongside metabolic and translation genes in M-like cells suggests a housekeeping/antigen-handling program. The treatment-responsive upregulation in CD may reflect restoration of normal macrophage function. The strongest coherent theme across hub genes is general housekeeping with antigen handling capacity.
Genes
Most correlated modules
- Inflammatory Activation Stress · correlation 0.99
- Oxidative Stress Response · correlation 0.99
- ER Protein Homeostasis · correlation 0.98
- Intestinal Stem Cell · correlation 0.98
- RNA Processing Homeostasis · correlation 0.98
- Interferon Antigen Processing · correlation 0.97
- Nuclear Transport RNA · correlation 0.97
- Metabolic Housekeeping · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.