OxPhos & Mitochondrial
Gene co-expression module in Microfold-like cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include NDUFB2 (Complex I, OxPhos), COX7B (Complex IV, OxPhos), UQCRQ (Complex III, OxPhos), PRDX5 (mitochondrial peroxiredoxin/antioxidant), ALKBH7 (mitochondrial RNA demethylase), PYCARD (ASC/inflammasome adaptor), TSTD1 (thiosulfate sulfurtransferase, mitochondrial), C12orf57 (poorly characterized). The module is anchored by multiple mitochondrial respiratory chain subunits (NDUFB2, COX7B, UQCRQ) and mitochondrial maintenance genes (ALKBH7, PRDX5, TSTD1). PYCARD is notable as an inflammasome component but is likely co-expressed here due to metabolic coupling in M-like cells. Neighbor modules M34 and M79 are also OxPhos-enriched, confirming this neighborhood represents mitochondrial programs.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.99
- OxPhos & Mitochondrial · correlation 0.99
- Colonocyte Differentiation · correlation 0.99
- OxPhos & Mitochondrial · correlation 0.98
- Chaperone Proteostasis · correlation 0.98
- Epithelial Metabolic Housekeeping · correlation 0.98
- ER Protein Homeostasis · correlation 0.98
- Metabolic Detoxification · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.