Metabolic Housekeeping
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include TPI1 (glycolysis), PKM (glycolysis, pyruvate kinase), ETFB (electron transfer flavoprotein, mitochondrial FAO), UQCRC1 (complex III, OxPhos), HSPB1 (small heat shock protein/stress), MZT2B (microtubule nucleation), AKAP1 (mitochondrial anchoring), MPST (sulfur metabolism), CLDN7 (tight junction/epithelial integrity), LMNA (nuclear lamina), CTSD (lysosomal protease). This is a mixed metabolic/housekeeping module combining glycolysis, mitochondrial respiration, and structural genes. The presence of HSPB1 and CTSD adds a mild stress/proteostasis flavor. Neighbor modules are similarly metabolic. Best classified as a general metabolic housekeeping program.
Genes
Most correlated modules
- ER Protein Homeostasis · correlation 0.99
- OxPhos & Mitochondrial · correlation 0.98
- Epithelial Metabolic Housekeeping · correlation 0.98
- Oxidative Stress Response · correlation 0.98
- OxPhos & Mitochondrial · correlation 0.98
- OxPhos & Mitochondrial · correlation 0.97
- Inflammatory Activation Stress · correlation 0.97
- Antigen Presentation Housekeeping · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.