OxPhos & Mitochondrial
Gene co-expression module in Microfold-like cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include NDUFS5 (Complex I, OxPhos), ATP5MC3 and ATP5MC1 (ATP synthase subunits, Complex V), UQCRH (Complex III), TUFM (mitochondrial translation elongation factor), EEF1B2 (cytoplasmic translation elongation), SNU13 (snRNP/ribosome biogenesis), NSA2 (ribosome biogenesis), PPP1R14B (protein phosphatase inhibitor). The module is dominated by mitochondrial respiratory chain components and translation factors, indicating a mitochondrial biogenesis/OxPhos program. Downregulated in inflammation, restored with CD treatment. Consistent with neighbor modules (M71, M79) also enriched in OxPhos subunits.
Genes
Most correlated modules
- OxPhos & Mitochondrial · correlation 0.99
- ER Protein Homeostasis · correlation 0.99
- RNA Processing Homeostasis · correlation 0.99
- Oxidative Phosphorylation · correlation 0.99
- Chaperone Proteostasis · correlation 0.98
- Mitochondrial OxPhos · correlation 0.98
- Intestinal Stem Cell · correlation 0.98
- Inflammatory Activation Stress · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.