Chromatin Stress Recovery
Gene co-expression module in Microfold-like cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes NOLC1 (nucleolar/ribosome biogenesis), BAG1 (BAG family co-chaperone, anti-apoptotic), TMEM123 (transmembrane, phosphatidylserine flippase-related), EPHA2 (Eph receptor tyrosine kinase, cell adhesion/migration), VMP1 (autophagy/ER stress), NCOA7 (nuclear receptor coactivator, antiviral), EDN1 (endothelin-1, vasoactive/inflammatory peptide), SMARCC1 (SWI/SNF chromatin remodeling). Module is significantly upregulated by CD treatment and downregulated in CD inflammation. The gene set is heterogeneous: chromatin remodeling (SMARCC1), autophagy (VMP1), receptor signaling (EPHA2), chaperone (BAG1), nucleolar (NOLC1), and inflammatory mediator (EDN1). The strongest unifying theme may be chromatin regulation and stress response. SMARCC1 and NOLC1 point to transcriptional/chromatin programs; BAG1 and VMP1 to stress/autophagy. This module may represent a chromatin remodeling/stress recovery program in M-like cells during treatment response.
Genes
Most correlated modules
- RNA Processing Homeostasis · correlation 0.97
- Nuclear Transport RNA · correlation 0.97
- Mitochondrial Assembly · correlation 0.97
- Antigen Presentation Housekeeping · correlation 0.97
- Intestinal Stem Cell · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.