RNA Processing Homeostasis
Gene co-expression module in Microfold-like cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes MARCKS (membrane/actin signaling), LSM2 (RNA splicing/processing), HNRNPA1 (RNA binding/splicing), MRPS34 (mitochondrial ribosome), PRDX2 (peroxiredoxin, antioxidant), CUTA (copper metabolism), PPA1 (inorganic pyrophosphatase, housekeeping metabolism), HNRNPM (RNA binding), B3GNT7 (glycosyltransferase). Module is significantly downregulated in both UC and CD inflammation and restored by CD treatment. The gene set is heterogeneous but dominated by RNA processing (LSM2, HNRNPA1, HNRNPM) and housekeeping metabolic functions (PPA1, PRDX2, MRPS34). The anti-inflammatory pattern (decreased in active disease, restored by treatment) and the housekeeping/RNA processing gene composition suggest this represents a baseline homeostatic RNA processing program that is suppressed during active inflammation. Neighbor context: this module neighbors M85 which also has strong RNA processing/hnRNP content, supporting a shared RNA processing neighborhood.
Genes
Most correlated modules
- Mitochondrial OxPhos · correlation 0.99
- OxPhos & Mitochondrial · correlation 0.99
- Inflammatory Activation Stress · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- ER Protein Homeostasis · correlation 0.98
- Protein Processing ER · correlation 0.98
- Intestinal Stem Cell · correlation 0.98
- Chaperone Proteostasis · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.