Nuclear Transport RNA
Gene co-expression module in Microfold-like cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes IPO7 (importin 7, nuclear import), CCT2 (chaperonin complex, protein folding), HNRNPF (RNA splicing/processing), PPM1G (protein phosphatase, splicing regulation), EIF4H (translation initiation), KPNB1 (importin beta, nuclear transport), PRKAR2A (PKA regulatory subunit), ZDHHC3 (palmitoyl transferase), OAT (ornithine aminotransferase), FKBP3 (FK506-binding, chromatin). Module is significantly downregulated in both UC and CD inflammation and restored by CD treatment. The dominant theme is nuclear transport (IPO7, KPNB1) and RNA processing/translation (HNRNPF, PPM1G, EIF4H, CCT2). This is a housekeeping/RNA processing module suppressed during inflammation. Neighbor context: M94 also features hnRNP proteins and is similarly anti-correlated with inflammation, strongly supporting a shared RNA processing/nuclear transport neighborhood that reflects homeostatic M-like cell function.
Genes
Most correlated modules
- Protein Processing ER · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- Protein Homeostasis · correlation 0.98
- DNA Damage Response · correlation 0.98
- Chromatin Stress Recovery · correlation 0.97
- RNA Processing Homeostasis · correlation 0.97
- Mitochondrial Assembly · correlation 0.97
- Antigen Presentation Housekeeping · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.