Mitochondrial Assembly
Gene co-expression module in Microfold-like cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include PRDX4 (peroxiredoxin 4, ER-localized antioxidant/oxidoreductase), C1QBP (complement C1q binding protein, mitochondrial matrix, regulates mitochondrial translation and oxidative phosphorylation), COA4 (cytochrome c oxidase assembly factor 4), MRPL11 (mitochondrial ribosomal protein L11), HACD3 (3-hydroxyacyl-CoA dehydratase 3, fatty acid elongation in ER), RANBP1 (Ran GTPase binding protein, nuclear-cytoplasmic transport), NOP58 (nucleolar protein, rRNA processing), NAP1L1 (nucleosome assembly protein), ABLIM1 (actin-binding LIM protein), ERRFI1 (EGFR feedback inhibitor/MIG6). The mitochondrial assembly/function genes (C1QBP, COA4, MRPL11) and ER redox (PRDX4) dominate. Decreased in both UC and CD inflammation, restored with CD treatment — consistent with mitochondrial homeostasis loss during inflammation.
Genes
Most correlated modules
- RNA Processing Homeostasis · correlation 0.97
- Nuclear Transport RNA · correlation 0.97
- Colonocyte Proliferative Recovery · correlation 0.97
- Chromatin Stress Recovery · correlation 0.97
- Colonocyte Lipid Ion Transport · correlation 0.97
- Mucosal Restitution Secretory · correlation 0.97
- Interferon Antigen Processing · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.