BMP Developmental Identity
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Extremely low expression (0.8% positive), core coherence. BMP3, TLL2 (BMP processing metalloprotease), EN1 (engrailed developmental TF), SMOC2 (SPARC-related ECM), VEGFD (lymphangiogenic growth factor), ALCAM (developmental adhesion molecule), and LRRTM1 (developmental synaptic/positional gene) collectively define a rare developmental/positional fibroblast identity program involving BMP signaling. No significant disease association, suggesting a constitutive positional identity rather than a reactive state.
Genes
ALCAM, BMP3, EN1, KANK4, LRRC38, LRRTM1, LY6H, PRSS2, SLC35F3, SMOC2, TLL2, VEGFD
Most correlated modules
- Adventitial Fibroblast State · correlation 0.84
- Homeostatic Stromal Identity · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.