Adventitial Fibroblast State
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 18 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
Core coherence but extremely low expression (1.4% positive). PTGIS (prostacyclin synthase), CALCRL (CGRP receptor), SFRP5 (Wnt antagonist), COL21A1, CYP1B1, and PDGFRL suggest a rare vascular-associated or adventitial fibroblast subtype with anti-inflammatory Wnt-inhibitory character. Strong remission association. BLNK is anomalous but insufficient to call B-cell contamination given the overall stromal gene profile.
Genes
AKAP7, BLNK, C1QA, CACNA1G, CALCRL, COL21A1, CYP1B1, FAT3, KIRREL2, KRT7, OPCML, PDGFRL, PPP1R9A, PTGIS, SFRP5, TESC, TSPAN7, ZNF804A
Most correlated modules
- BMP Developmental Identity · correlation 0.84
- ECM Glycan Remodeling · correlation 0.81
- Heparan Sulfate Remodeling · correlation 0.71
- TGF-beta Response · correlation 0.65
- Retinoid Stromal Quiescence · correlation 0.64
- Fibroblast Niche Identity · correlation 0.59
- Homeostatic Stromal Identity · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.