Homeostatic Stromal Identity
Gene co-expression module in Fibroblasts
| Category | ECM production |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes ADAMTSL1/3 (ECM glycoproteins), KAZALD1 (IGFBP-related ECM), NFIB (fibroblast identity TF), LRIG1 (stem niche/quiescence marker), VEGFB, and PDE5A collectively define a homeostatic stromal fibroblast program. Upregulated in remission, downregulated in inflammation, consistent with a quiescent ECM-maintaining fibroblast state lost during active IBD.
Genes
ADAMTSL1, ADAMTSL3, EPB41L2, KAZALD1, LRIG1, NFIB, NUPR1, PDE5A, PLXDC1, SSPN, STEAP4, VEGFB, ZNF704
Most correlated modules
- TGF-beta Response · correlation 0.69
- BMP-antagonizing Fibroblast · correlation 0.60
- Submucosal Fibroblast · correlation 0.60
- Quiescent Anti-inflammatory Fibroblast · correlation 0.59
- Wnt-niche Fibroblast · correlation 0.58
- Adventitial Fibroblast State · correlation 0.57
- Quiescent Stromal Identity · correlation 0.57
- BMP Developmental Identity · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.