ALCAM — Activated leukocyte cell adhesion molecule
ALCAM belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ALCAM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | BMP Developmental Identity Developmental | BMP3, EN1, KANK4, LRRC38, LRRTM1, LY6H, PRSS2, SLC35F3 +3 more | View in SCUBA |
| Glial cells | Neural Migration Scaffold Cytoskeletal | ABLIM1, ANK3, CAB39L, GAS2L3, GFRA3, IQGAP2, NRXN1, RELN +1 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Identity Valve formation | C12orf57, C17orf58, CFH, CLDN11, DEGS2, EBPL, EDNRB, GJA4 +13 more | View in SCUBA |
| Macrophages | Hypoxia-driven Activation Inflammatory | ACVR1B, ADAM10, ADAM9, ANO6, B3GNT2, BTG1, C5AR1, CAB39 +33 more | View in SCUBA |
About the gene
| Synonyms | CD166, MEMD |
|---|---|
| Chromosome | 3: 105366909-105576900 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters |
| Biological process | Adaptive immunity, Cell adhesion, Immunity |
Function
Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation. Required for normal hematopoietic stem cell engraftment in the bone marrow. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.