ISG Regulatory Program
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes include PML and SP100 (nuclear body components, classical ISGs), ADAR (RNA editing enzyme, ISG), USP25 (deubiquitinase regulating innate immune signaling), KDM6A (histone demethylase), U2AF2 (splicing factor), and PRKD2 (protein kinase D2). The module combines nuclear body/ISG components (PML, SP100, ADAR), ubiquitin regulation (USP25, FBXL14, NUB1), and chromatin/RNA processing factors. In the context of neighboring interferon modules (M143, M145, M179), this module likely represents the chromatin remodeling, RNA editing, and ubiquitin regulatory arm of the interferon response rather than a core ISG module. The upregulation in CD inflammation supports an immune activation context.
Genes
Most correlated modules
- Circadian Clock Regulation · correlation 0.92
- Innate Immune Sensing · correlation 0.90
- Purinergic Receptor Signaling · correlation 0.87
- Membrane Lipid Signaling · correlation 0.85
- RNA & Membrane Housekeeping · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.