RNA & Membrane Housekeeping
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 13 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes include FLOT2 (lipid raft scaffold), TM9SF3 (membrane trafficking), PRPF8/SNRNP200 (pre-mRNA splicing), CAPRIN1/HNRNPUL2 (RNA granule/binding), EIF4G1 (translation initiation), HS2ST1/EXTL3 (heparan sulfate biosynthesis), DNM2 (dynamin/endocytosis), FYCO1 (autophagy), TRAPPC9 (vesicle tethering), SYK (mast cell kinase). Uniform low expression across all subsets. This module combines large housekeeping genes spanning RNA processing, membrane trafficking, and translation — characteristic of a broad housekeeping/large-gene co-expression module driven by transcriptional output rather than a specific biological program.
Genes
Most correlated modules
- Rho GTPase Signaling · correlation 0.93
- RAS/Rho GTPase Signaling · correlation 0.91
- Calcium Store Signaling · correlation 0.89
- Autophagy Lysosomal Program · correlation 0.88
- Cellular Housekeeping Mixed · correlation 0.88
- Membrane Lipid Signaling · correlation 0.87
- STAT6 IL-4 Signaling · correlation 0.86
- SMC Chromatin Maintenance · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.