Circadian Clock Regulation
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 13 of 23 genes have a known function matching the annotation |
Why this annotation
BMAL1 is a master circadian clock transcription factor (CLOCK/BMAL1 heterodimer). CRTC2 is a CREB co-activator that interacts with circadian regulatory pathways and is regulated by AMPK/LKB1. ADK (adenosine kinase) modulates adenosine levels linked to circadian metabolic cycles. KDM4C, ATF7IP, and MSL2 are chromatin regulators that modulate circadian gene accessibility. RRN3 (RNA Pol I initiation), POLR3C (RNA Pol III subunit), TENT2 (cytoplasmic poly(A) polymerase), and SCAF8 (RNA Pol II CTD-associated) reflect transcriptional regulation. PIAS1 (SUMO E3 ligase) SUMOylates BMAL1 to regulate circadian amplitude. The significant delta_inflammation_CD association and negative delta_remission_UC suggest circadian disruption in IBD. This module represents circadian clock and chromatin regulatory co-expression.
Genes
Most correlated modules
- RAS/Rho GTPase Signaling · correlation 0.96
- PD-L1 Checkpoint Program · correlation 0.95
- Mast Cell Homeostasis · correlation 0.94
- Transcriptional Metabolic Regulation · correlation 0.94
- Autophagy Lysosomal Program · correlation 0.94
- Mast Cell Identity · correlation 0.94
- Ubiquitin-Chromatin Regulation · correlation 0.93
- Calcium Store Signaling · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.