Membrane Lipid Signaling
Gene co-expression module in Mast cells
| Category | Degranulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include ANO6 (anoctamin-6/TMEM16F, calcium-activated phospholipid scramblase involved in phosphatidylserine exposure, platelet activation, and mast cell degranulation), TSPAN14 (tetraspanin regulating ADAM10 sheddase activity and immune cell signaling), SH2B1 (JAK2/insulin receptor signaling adapter), PKN1 (protein kinase N, downstream of Rho GTPases), TRIM5 (E3 ubiquitin ligase/antiviral), BMPR2 (BMP receptor, growth/differentiation signaling), FNIP2 (FLCN-interacting protein, mTORC1 regulation), TMEM87B (membrane protein). ANO6 is particularly relevant to mast cell membrane biology and degranulation-associated phospholipid scrambling. The module is heterogeneous but has a membrane signaling/lipid theme.
Genes
Most correlated modules
- Rho GTPase Signaling · correlation 0.91
- RNA & Membrane Housekeeping · correlation 0.87
- Quiescence Epigenetic · correlation 0.86
- ISG Regulatory Program · correlation 0.85
- RNA Decay Processing · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.