p38-MK2 Stress Signaling
Gene co-expression module in Mast cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
MAPKAPK2 (MK2) is the top functional hub — it is a direct substrate of p38 MAPK and a central effector of the p38 stress/inflammatory signaling pathway, regulating mRNA stability, cytokine production, and stress granule formation. ATXN2L is associated with stress granules and RNA granule biology. EIF4G2 (DAP5) is a translation initiation factor active during stress. SFPQ is an RNA-binding protein involved in stress responses. SEC14L1 is a lipid transfer protein. AP1G1 is part of the AP-1 adaptor complex for vesicle trafficking. HMCES protects against replication stress. The module combines p38/MK2 stress signaling with RNA processing and stress granule biology. Neighbor modules M70 and M72 also show transcriptional regulatory programs, consistent with a stress-response neighborhood.
Genes
Most correlated modules
- TGF-beta Repression · correlation 0.85
- RNA & Protein Homeostasis · correlation 0.82
- NFAT Mast Cell Activation · correlation 0.81
- Transcriptional Regulation · correlation 0.75
- Histone Ubiquitination · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.