NFAT Mast Cell Activation
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
NFATC1 is the top hub gene and a master transcription factor for mast cell activation, osteoclastogenesis, and immune cell differentiation — it is directly activated downstream of FcεRI and calcium signaling in mast cells. PRKCD (PKC-delta) is a key kinase in mast cell signaling and can regulate both activation and apoptosis. NR4A3 is an immediate-early nuclear receptor induced by mast cell activation signals. MAFF is a stress-responsive bZIP factor. GCH1 encodes GTP cyclohydrolase I, the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, relevant to NO production and oxidative stress. USP15 and RNF103 regulate ubiquitin-dependent signaling. STX5 is a SNARE protein involved in vesicle fusion/secretion. PSME4 (PA200) is a proteasome activator. The module is anchored by NFATC1/PRKCD mast cell activation signaling with downstream transcriptional and secretory components.
Genes
Most correlated modules
- Endosomal Autophagy Trafficking · correlation 0.87
- NF-κB Immediate Response · correlation 0.85
- RNA & Protein Homeostasis · correlation 0.85
- LXR/PPAR Repression · correlation 0.83
- p38-MK2 Stress Signaling · correlation 0.81
- Mast Cell Activation · correlation 0.79
- TGF-beta Repression · correlation 0.78
- MAPK-AP1 Signaling · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.