RNA & Protein Homeostasis
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 13 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include PAF1 (RNA Pol II elongation complex), UPF3B (nonsense-mediated mRNA decay), SRSF4 (splicing), COPA (COPI vesicle trafficking), WEE1 (cell cycle kinase G2/M checkpoint), CUL3 (ubiquitin E3 ligase), GOLGB1 (Golgi matrix), HNRNPU (RNA binding), MORF4L2 (chromatin). This is a mixed housekeeping module spanning transcription elongation, RNA surveillance, splicing, vesicle trafficking, and ubiquitin-proteasome regulation. Uniform expression across subsets, low pct positive, no strong disease association. Neighbor modules (M73, M72) also show broad regulatory/housekeeping programs, consistent with a co-expression neighborhood of general cellular maintenance genes.
Genes
Most correlated modules
- LXR/PPAR Repression · correlation 0.88
- NF-κB Activation · correlation 0.87
- General Housekeeping · correlation 0.86
- DNA Damage Response · correlation 0.86
- NFAT Mast Cell Activation · correlation 0.85
- mRNA Processing · correlation 0.83
- TGF-beta Repression · correlation 0.82
- p38-MK2 Stress Signaling · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.