TGF-beta Repression
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes SKIL (SnoN) and TGIF2 are canonical negative regulators of TGF-beta/SMAD signaling. CCNT1 (Cyclin T1) partners with CDK9 in P-TEFb for transcription elongation. SIRT1 is a deacetylase that modulates TGF-beta and stress responses. RB1 is a cell cycle/transcriptional repressor. ERF is an ETS-family transcriptional repressor. TSC22D2 is a transcriptional repressor. DUSP5 is a MAPK phosphatase. TP53INP2 links p53 and autophagy. The convergence of SKIL, TGIF2, SIRT1, and RB1 suggests a TGF-beta pathway regulatory module with transcriptional repression character. Neighbor M188 covers general transcription; this module is more specifically TGF-beta/growth suppressive signaling.
Genes
Most correlated modules
- p38-MK2 Stress Signaling · correlation 0.85
- RNA & Protein Homeostasis · correlation 0.82
- NFAT Mast Cell Activation · correlation 0.78
- Pre-mRNA Splicing · correlation 0.74
- Transcriptional Regulation · correlation 0.70
- NF-κB Activation · correlation 0.69
- RNA Splicing · correlation 0.69
- Immediate Early Response · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.