Epigenetic Transcriptional Control
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 30 genes have a known function matching the annotation |
Why this annotation
Hub genes include multiple zinc finger transcription factors (ZNF490, ZNF292, ZNF737, ZNF638), chromatin/epigenetic regulators KMT2A (MLL1 histone H3K4 methyltransferase) and SETDB1 (H3K9 methyltransferase), PI3K signaling components PIK3R1 (p85 regulatory subunit) and IRS2 (insulin receptor substrate linking to PI3K/Akt), TRAF3IP3 (TRAF3-interacting protein in immune signaling), and GIT2/RHOBTB3 (GTPase regulators). The module combines epigenetic/transcriptional regulation with PI3K signaling. TRAF3IP3 links to NF-kB and interferon pathways. Mild CD inflammation signal. This module likely represents a chromatin regulatory and transcriptional control program in mast cells, potentially governing inflammatory gene expression.
Genes
Most correlated modules
- Mast Cell Identity · correlation 0.92
- Mast Cell Identity · correlation 0.92
- Lysosomal Autophagy · correlation 0.92
- Mast Cell Specification · correlation 0.90
- Calcium-GPCR Signaling · correlation 0.90
- Chromatin Remodeling · correlation 0.90
- PI3K Inflammatory Signaling · correlation 0.89
- Eicosanoid Biosynthesis · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.