Histone Methylation Regulation
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include KMT2C (H3K4 methyltransferase), EHMT1 (H3K9 methyltransferase), SETD2 (H3K36 methyltransferase) — three histone methyltransferases. HUWE1, TRIP12, BIRC6 are large E3 ubiquitin ligases. NUMA1 and CEP350 are centrosomal/mitotic. MACF1 is a cytoskeletal linker. NCOA2 is a nuclear receptor coactivator. DCTN1 is dynactin. The dominant theme is chromatin/epigenetic regulation via histone methylation, co-expressed with large ubiquitin ligases. Uniform expression suggests housekeeping-level chromatin maintenance rather than an activated program.
Genes
Most correlated modules
- Immune Activation Signaling · correlation 0.92
- General Cellular Maintenance · correlation 0.85
- ER & Vesicle Trafficking · correlation 0.84
- RNA Decay Processing · correlation 0.83
- Chromatin Epigenetic Regulation · correlation 0.82
- STAT5 Cytokine Signaling · correlation 0.82
- Actin Cytoskeleton Organization · correlation 0.82
- Post-transcriptional Regulation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.