Chromatin Cell Cycle
Gene co-expression module in Mast cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include linker histones H1-3 and H1-4 (chromatin compaction), centromere/centrosome proteins CENPT and CEP120 (mitotic apparatus), ATXN7L1 (SAGA chromatin complex), CTBP1 (transcriptional corepressor), and ATG16L2 (autophagy). The combination of histone H1 variants with centromere proteins points to a cell cycle-associated chromatin regulation program, particularly chromatin reorganization during cell division. OS9 (ER quality control) and RABGAP1L (vesicle trafficking) are peripheral members. No strong mast cell subset enrichment; uniform low expression consistent with a cycling subpopulation.
Genes
Most correlated modules
- Mast Cell Identity · correlation 0.92
- Rho GTPase Signaling · correlation 0.92
- Chromatin Remodeling · correlation 0.92
- RAS/Rho GTPase Signaling · correlation 0.91
- Mast Cell Identity · correlation 0.91
- NF-κB Signaling · correlation 0.89
- Glucocorticoid Stress Response · correlation 0.89
- PI3K Inflammatory Signaling · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.