SMC Chromatin Maintenance
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include SMCHD1 (structural maintenance of chromosomes hinge domain — chromatin silencing), SMC5 (SMC complex member, DNA repair/cohesion), SAFB2 (scaffold attachment factor, chromatin/RNA), PUM1 (Pumilio RNA-binding translational repressor), CPSF7 (cleavage/polyadenylation specificity factor), BDP1 (RNA Pol III subunit), SNRNP70 (U1 snRNP splicing), SENP6 (SUMO-specific protease), SMAD4 (TGF-β/BMP canonical signaling), HECTD1 (E3 ubiquitin ligase). Significantly upregulated in UC inflammation. The module combines chromatin/SMC complex genes with RNA processing and SMAD4 TGF-β signaling. The UC inflammation association and SMAD4 presence suggest a TGF-β/chromatin regulatory program active in inflammation.
Genes
Most correlated modules
- Cellular Housekeeping Mixed · correlation 0.85
- RNA & Membrane Housekeeping · correlation 0.85
- Phosphoinositide Cytoskeletal Signaling · correlation 0.85
- RNA Decay Processing · correlation 0.83
- ER & Vesicle Trafficking · correlation 0.81
- Histone Methylation Regulation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.