Rho GTPase Signaling
Gene co-expression module in Mast cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 29 genes have a known function matching the annotation |
Why this annotation
Hub genes include ARHGEF1, ARHGEF18 (Rho guanine nucleotide exchange factors), ARFGEF1 (ARF GEF for vesicle trafficking), RAB11FIP3 (RAB11 effector, endosomal recycling), PTK2B (focal adhesion kinase 2), and MAPK8IP3 (JNK scaffold). These collectively point to Rho/ARF GTPase-mediated cytoskeletal and vesicle trafficking regulation. SPEN and SMARCA2 add chromatin/transcriptional regulation, and CDKN1B (p27) suggests cell cycle context. The module is upregulated in UC inflammation. The dominant program is Rho GTPase signaling and cytoskeletal organization.
Genes
Most correlated modules
- RAS/Rho GTPase Signaling · correlation 0.97
- Mast Cell Identity · correlation 0.94
- JAK-TEC Signaling · correlation 0.94
- Calcium Store Signaling · correlation 0.94
- RNA & Membrane Housekeeping · correlation 0.93
- Circadian Clock Regulation · correlation 0.93
- Chromatin Cell Cycle · correlation 0.92
- PD-L1 Checkpoint Program · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.