Quiescence Epigenetic
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include MS4A4E (MS4A family member expressed in mast cells/macrophages), TTN (titin, structural/mechanosensing protein, also expressed in non-muscle cells), CCDC141 (coiled-coil domain, cytoskeletal), EZH1 (PRC2 histone methyltransferase, epigenetic silencing), MAML2 (Mastermind-like 2, Notch transcriptional co-activator), FOXO4 (FOXO transcription factor, stress response/quiescence), CCNG2 (cyclin G2, cell cycle inhibitor/quiescence marker), DOCK4 (Rac GEF, cytoskeletal/migration). The combination of FOXO4, CCNG2, and EZH1 suggests a quiescence/epigenetic silencing program. MAML2 adds Notch signaling. MS4A4E anchors this to mast cells. Decreased in UC remission. The module may reflect a mast cell quiescence/epigenetic state.
Genes
Most correlated modules
- Mast Cell Identity · correlation 0.91
- PI3K Inflammatory Signaling · correlation 0.88
- Epigenetic Transcriptional Control · correlation 0.87
- NF-κB Signaling · correlation 0.87
- JAK-TEC Signaling · correlation 0.87
- TGF-beta Tolerance · correlation 0.87
- Membrane Lipid Signaling · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.