Endosomal Trafficking
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include VTI1A (SNARE vesicle trafficking), HGS (ESCRT/endosomal sorting), SPPL3 (intramembrane protease/glycan trimming), NDUFV1 (mitochondrial complex I), ACADVL (fatty acid beta-oxidation), LIG3 and XRCC1 (DNA repair), STARD3 (lipid transfer/cholesterol). The module mixes endosomal trafficking, mitochondrial metabolism, and DNA repair — a loosely coherent housekeeping cluster. Uniform low expression and no significant disease response support constitutive activity.
Genes
Most correlated modules
- Autophagy Lysosomal Program · correlation 0.89
- DNA Damage Response · correlation 0.88
- Cellular Housekeeping Mixed · correlation 0.87
- Ubiquitin-Chromatin Regulation · correlation 0.84
- PI3K-Wnt Signaling · correlation 0.83
- General Housekeeping · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.