BRD4 Chromatin Regulation
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes include BRD4 (bromodomain/BET protein — transcriptional regulation, super-enhancers), UBE3A (E3 ubiquitin ligase/Angelman), SETD5 (H3K4 methyltransferase), MDC1 (mediator of DNA damage checkpoint 1 — DNA damage response), TBC1D5 (Rab7 GAP, endosomal trafficking), RAB11FIP2 (Rab11 effector, recycling endosome), PICALM (clathrin assembly, endocytosis), FBXW7 (SCF E3 ubiquitin ligase, tumor suppressor), QKI (RNA binding), SMAD2 (TGF-β signaling), COP1 (E3 ubiquitin ligase). BRD4 and SETD5 point to chromatin/transcriptional regulation; MDC1 to DNA damage. Upregulated in UC inflammation. The module is mixed but BRD4-centered chromatin/ubiquitin regulation is the dominant theme.
Genes
Most correlated modules
- Ubiquitin-Chromatin Regulation · correlation 0.88
- Housekeeping Signaling · correlation 0.85
- P-body mRNA Decay · correlation 0.84
- Actin Cytoskeleton Organization · correlation 0.83
- Ubiquitin-Chromatin Regulation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.