tRNA Aminoacylation
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Top hub genes POLR1H (RNA polymerase I subunit), AARSD1 (alanyl-tRNA synthetase domain-containing), TARS3 (mitochondrial threonyl-tRNA synthetase), NARS1 (asparaginyl-tRNA synthetase) define a strong aminoacyl-tRNA synthetase and RNA polymerase program. YJU2B is a splicing factor, ADPRS is an ADP-ribosylhydrolase, INO80B is a chromatin remodeler, LIN37 is part of the DREAM complex. All disease delta values are exactly 0.000, indicating this is a constitutively expressed housekeeping module with no disease modulation. The tRNA synthetase cluster is the dominant theme.
Genes
Most correlated modules
- RNA Processing & Mitochondrial · correlation 0.94
- Protein Homeostasis · correlation 0.92
- General Housekeeping · correlation 0.90
- Aminoacyl-tRNA Synthetase · correlation 0.89
- Mitochondrial Organization · correlation 0.89
- MARCH Ubiquitin Ligase · correlation 0.88
- Histone Variant Chromatin · correlation 0.88
- Aminoacyl-tRNA Synthetases · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.