General Housekeeping
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes TRAPPC5 (TRAPP tethering complex, vesicle trafficking/autophagy), GPS2 (G-protein pathway suppressor 2, transcriptional corepressor and mitochondrial import regulator), H2AZ2 (histone H2A variant, chromatin regulation), TLE5 (Groucho/TLE transcriptional repressor), RBIS, ANTKMT (mitochondrial adenine nucleotide translocator lysine methyltransferase), SLX9 (ribosome biogenesis factor). Small module with mixed functions: vesicle trafficking (TRAPPC5), chromatin/transcription (H2AZ2, TLE5, GPS2), mitochondrial (ANTKMT), and ribosome biogenesis (SLX9). The module is small (10 genes) with all core membership, suggesting a tight but functionally heterogeneous housekeeping cluster. Neighbors with mitochondrial and chromatin themes support this interpretation.
Genes
Most correlated modules
- Mitochondrial Organization · correlation 0.96
- Histone Variant Chromatin · correlation 0.96
- Protein Homeostasis · correlation 0.94
- RNA Processing & Mitochondrial · correlation 0.91
- tRNA Aminoacylation · correlation 0.90
- Aminoacyl-tRNA Synthetase · correlation 0.90
- Aminoacyl-tRNA Synthetases · correlation 0.81
- Mitochondrial Protein Import · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.