Mitochondrial Organization
Gene co-expression module in Mast cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes include GABARAP (autophagy receptor/LC3 family), SEPTIN7 (cytoskeletal GTPase), H3-3A and H3-3B (histone H3.3 variants), TOMM6 (TOM complex, mitochondrial protein import), MICOS10 and MICOS13 (mitochondrial inner membrane organizing system), ATP5MK and NDUFA13 (mitochondrial ATP synthase and Complex I subunits), NME2 (nucleoside diphosphate kinase), ATP6V0C (V-ATPase subunit), MIF (macrophage migration inhibitory factor, pro-inflammatory cytokine), UBE2V1 (ubiquitin-conjugating enzyme). The module has a strong mitochondrial component (TOMM6, MICOS10, MICOS13, ATP5MK, NDUFA13) alongside autophagy (GABARAP) and histones. Significantly increased with UC inflammation and strongly decreased with remission, suggesting mitochondrial/metabolic upregulation in active disease. Neighbor M201 also has mitochondrial ribosomal genes.
Genes
Most correlated modules
- General Housekeeping · correlation 0.96
- Histone Variant Chromatin · correlation 0.90
- Protein Homeostasis · correlation 0.90
- tRNA Aminoacylation · correlation 0.89
- Aminoacyl-tRNA Synthetase · correlation 0.88
- RNA Processing & Mitochondrial · correlation 0.85
- Aminoacyl-tRNA Synthetases · correlation 0.79
- Mitochondrial Protein Import · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.